The National Transportation Safety Board launched a full Go-Team to investigate Wednesday morning's crash of a UPS Airbus A300.
Flight 1354 from Louisville, Kentucky, to Birmingham crashed on approach to Runway 18 at Birmingham International Airport around 5 a.m.
The plane crashed in an open area outside the airport fence. Two crew members, the pilot and co-pilot, were killed in the crash, according to Birmingham Mayor William Bell.
Family members confirmed Shanda Fanning, of Lynchburg, Tennessee, was one of the crew members on board the plane, according to WSMV.
UPS said they have not confirmed the status of their pilots, but did say the plane had two crew members on board.
"This incident is very unfortunate, and our thoughts and prayers are with those involved," said UPS Airlines President Mitch Nichols.
It appears the plane clipped some trees and power lines before it crashed. Officials said debris from the wreckage is spread over about a half-mile around the crash site. No injuries have been reported on the ground.
Crews have closed off streets in surrounding neighborhoods to expand the search zone.
Mayor Bell said there was no distress signal at the Birmingham airport tower.
Officials with the Birmingham-Shuttlesworth Airport said the crash will not impact air traffic.
The NTSB will hold a news conference at 4 p.m. in Birmingham on Wednesday. You can watch it LIVE on WAFF.com and on our mobile news app.
Copyright 2013 WAFF. All rights reserved. WBRC contributed to this report.