NEWBURYPORT, Mass. (AP) — A hazardous materials team responded to a pharmaceutical chemical plant in Massachusetts on Thursday morning after firefighters reported hearing several explosions in the building, authorities said.

Firefighters responding to a fire alarm went to the PCI Synthesis building in Newburyport at about 4:30 a.m. heard three explosions so evacuated the building, Deputy Fire Chief Stephen Bradbury said.

There were three more explosions about 15 minutes later, including one that blew an eight-foot wide hole in the roof, he said.

There were workers in the building at the time but no reports of injuries, authorities said.

The cause of the explosions remains under investigation.

A spokeswoman for the state Fire Marshal said a hazardous materials team was sent to the scene.

Three nearby businesses were closed for the day as a precaution, Bradbury said.

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